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Santa Cruz Biotechnology
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Becton Dickinson
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Merck KGaA
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Merck KGaA
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Becton Dickinson
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Becton Dickinson
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Becton Dickinson
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R&D Systems
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NSJ Bioreagents
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Santa Cruz Biotechnology
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Vector Laboratories
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Image Search Results
Journal: Environmental toxicology
Article Title: Interleukin-4 inhibits the hypothalamic appetite control by modulating the insulin-AKT and JAK-STAT signaling in leptin mutant mice.
doi: 10.1002/tox.24264
Figure Lengend Snippet: FIGURE 3 IL-4 activates insulin receptor and JAK2-STAT3 signaling in hypothalamus of 145E mice. Levels of p-IRβ, p-AKT, p-JAK2, p-STAT6, and p-STAT3 were analyzed by Western blot analysis (A) and quantified in (B) and (C). (D) SOCS3 and SOCS1 mRNA levels were examined by real-time PCR in wild type (WT) (N = 8) and 145E (N = 8) mice treated with PBS or IL-4. *p < .05; **p < .01; ***p < .001. IL, interleukin; SOCS, suppressors of cytokine signaling.
Article Snippet: Antibodies against JAK2, phosphorylated JAK2 Tyr221, STAT6 (from Cell Signaling Technology, Danvers, MA, USA), STAT3,
Techniques: Western Blot, Real-time Polymerase Chain Reaction
Journal: Environmental toxicology
Article Title: Interleukin-4 inhibits the hypothalamic appetite control by modulating the insulin-AKT and JAK-STAT signaling in leptin mutant mice.
doi: 10.1002/tox.24264
Figure Lengend Snippet: FIGURE 5 Molecular mechanism underlying the effects of IL-4 on hypothalamic appetite control. IL-4 stimulates leptin and insulin signaling, leads to activation of JAK2-STAT3 and IR- AKT, which promotes proopiomelanocortin (POMC) and suppress agouti-related peptide (AgRP)/neuropeptide Y (NPY) production, and inhibits proinflammatory cytokine expression. IL, interleukin; SOCS, suppressors of cytokine signaling.
Article Snippet: Antibodies against JAK2, phosphorylated JAK2 Tyr221, STAT6 (from Cell Signaling Technology, Danvers, MA, USA), STAT3,
Techniques: Control, Activation Assay, Expressing